Phytocannabinoid

THC (Delta-9 Tetrahydrocannabinol)

THC, or delta-9 tetrahydrocannabinol, is the primary psychoactive compound in cannabis. It activates the CB1 receptor in the central nervous system, producing the euphoric, perception-altering effects associated with cannabis use. Modern commercial cannabis flower typically contains 18%–28% THC.

Associated effects

euphoria, appetite stimulation, analgesia, altered perception

Delta-9 THC is the most studied phytocannabinoid and the molecule most commonly associated with cannabis intoxication. It is a partial agonist at the CB1 receptor in the central nervous system, which mediates the bulk of its psychoactive effects, and a weak agonist at CB2 receptors in the immune system. THC also has documented analgesic, anti-emetic, and appetite-stimulating effects that underpin the bulk of cannabis's medical use.

Frequently asked questions

What does THC do?

THC activates the CB1 cannabinoid receptor in the central nervous system, producing euphoria, altered sensory perception, appetite stimulation, analgesia, and the broader subjective effects of cannabis intoxication.

How much THC is in modern cannabis?

Modern commercial cannabis flower in U.S. adult-use markets typically tests at 18% to 28% THC by weight, with high-end cultivars occasionally exceeding 30%. Concentrate products can contain 60%–90% THC.