Phytocannabinoid

CBD (Cannabidiol)

CBD, or cannabidiol, is a non-intoxicating phytocannabinoid found in cannabis and hemp. It does not activate the CB1 receptor in the way THC does and produces no euphoria. CBD has documented anticonvulsant, anti-inflammatory, and anxiolytic effects, with FDA-approved use in specific epilepsy syndromes.

Associated effects

anti-inflammatory, anxiolytic, anticonvulsant

CBD is the second-most-abundant cannabinoid in cannabis and the dominant cannabinoid in most hemp varietals. Unlike THC, CBD does not bind appreciably to the CB1 receptor and therefore does not produce intoxication. Its pharmacology is broad and complex — CBD modulates the endocannabinoid system indirectly, inhibits CYP450 hepatic enzymes (creating clinically meaningful drug interactions), and binds to serotonin and TRPV receptors. CBD has FDA-approved use as Epidiolex for specific pediatric epilepsy syndromes.

Frequently asked questions

Does CBD get you high?

No. CBD does not activate the CB1 receptor in the way THC does and does not produce euphoria, perceptual changes, or intoxication.

Does CBD interact with medications?

Yes — meaningfully. CBD inhibits cytochrome P450 enzymes CYP3A4 and CYP2C9, which metabolize many common drugs including warfarin, certain anticonvulsants, immunosuppressants, and oncology agents. Discuss with a prescriber before starting CBD.